［1］Agliullina DG，Lapina LA，Vinter VG. Changes in the RNA content of the blood plasma in rats with Ehrlich ascitic cancer. Eksp Onkol，1988，10（4）：49-51，62.

［2］Tsui NB，Ng EK，Lo YM，Stability of endogenous and added RNA in blood specimens，serum，and plasma. Clin Chem，2002，48（10）：1647-1653.

［3］El-Hefnawy T，Raja S，Kelly L，et al. Characterization of amplifiable，circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem，2004，50（3）：564-573.

［4］Xu L，Yang BF，Ai J. MicroRNA transport：a new way in cell communication. J Cell Physiol，2013，228（8）：1713-1719.

［5］Yang B，Lin H，Xiao J，et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med，2007，13（4）：486-491.

［6］Ai J，Zhang R，Li Y，et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun，2010，391（1）：73-77.

［7］D′Alessandra Y，Carena MC，Spazzafumo L，et al. Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina. PLoS One，2013，8（11）：e80345.

［8］Ren J，Zhang J，Xu N，et al. Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. PLoS One，2013，8（12）：e80738.

［9］Fichtlscherer S，De Rosa S，Fox H，et al. Circulating microRNAs in patients with coronary artery disease. Circ Res，2010，107（5）：677-684.

［10］Heggermont WA，Heymans S，MicroRNAs are involved in end-organ damage during hypertension. Hypertension，2012，60（5）：1088-1093.

［11］Kontaraki JE，Marketou ME，Parthenakis FI，et al. Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. J Am Soc Hypertens，2015，9（10）：802-810.

［12］Karolina DS，Tavintharan S，Armugam A，et al. Circulating miRNA profiles in patients with metabolic syndrome. J Clin Endocrinol Metab，2012，97（12）：E2271-2276.

［13］Kumar P，Dezso Z，MacKenzie C，et al. Circulating miRNA biomarkers for Alzheimer’s disease. PLoS One，2013，8（7）：e69807.

［14］Khoo SK，Petillo D，Kang UJ，et al. Plasma-based circulating MicroRNA biomarkers for Parkinson’s disease. J Parkinsons Dis，2012，2（4）：321-331.

［15］Pescador N，Pérez-Barba M，Ibarra JM，et al. Serum circulating microRNA profiling for identification of potential type 2 diabetes and obesity biomarkers. PLoS One，2013，8（10）：e77251.

［16］Guay C，Regazzi R. Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol，2013，9（9）：513-521.

［17］Neal C，Michael MZ，Pimlott LK，et al. Circulating microRNA expression is reduced in chronic kidney disease. Nephrol Dial Transplant，2011，26（11）：3794-3802.

［18］Mlcochova H，Hezova R，Stanik M，et al. Urine microRNAs as potential noninvasive biomarkers in urologic cancers. Urol Oncol，2014，32（1）：41. e1-9.

［19］Park NJ，Zhou H，Elashoff D，et al. Salivary microRNA：discovery，characterization，and clinical utility for oral cancer detection. Clin Cancer Res，2009，15（17）：5473-5477.

［20］Do Canto LM，Marian C，Willey S，et al. MicroRNA analysis of breast ductal fluid in breast cancer patients. Int J Oncol，2016，48（5）：2071-2078.

［21］Jin L，Wessely O，Marcusson EG，et al. Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu，EGF，and TNF-alpha in breast cancer. Cancer Res，2013，73（9）：2884-2896.

［22］Levanen B，Bhakta NR，Torregrosa Paredes P，et al. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol，2013，131（3）：894-903.

［23］Na RS，E GX，Sun W，et al. Expressional analysis of immune-related miRNAs in breast milk. Genet Mol Res，2015，14（3）：11371-11376.

［24］Mun J，Tam C，Chan G，et al. MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. PLoS One，2013，8（2）：e57850.

［25］Lazzarini R，Olivieri F，Ferretti C，et al. mRNAs and miRNAs profiling of mesenchymal stem cells derived from amniotic fluid and skin：the double face of the coin. Cell Tissue Res，2014，355（1）：121-130.

［26］Weber JA，Baxter DH，Zhang S，et al. The microRNA spectrum in 12 body fluids. Clin Chem，2010，56（11）：1733-1741.

［27］Baraniskin A，Kuhnhenn J，Schlegel U，et al. Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma. Neuro Oncol，2012，14（1）：29-33.

［28］Teplyuk NM，Mollenhauer B，Gabriely G，et al. MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol，2012，14（6）：689-700.

［29］Tokuhisa M，Ichikawa Y，Kosaka N，et al. Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer. PLoS One，2015，10（7）：e0130472.

［30］Farrell JJ，Toste P，Wu N，et al. Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer. Am J Gastroenterol，2013，108（8）：1352-1359.

［31］Selth LA，Roberts MJ，Chow CW，et al. Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers. Endocr Relat Cancer，2014，21（4）：L17-21.

［32］Wang F，Long G，Zhao C，et al. Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for acute myocardial infarction. PLoS One，2014，9（9）：e105734.

［33］Wang GK，Zhu JQ，Zhang JT，et al. Circulating microRNA：a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J，2010，31（6）：659-666.

［34］Peng L，Chun-guang Q，Bei-fang L，et al. Clinical impact of circulating miR-133，miR-1291 and miR-663b in plasma of patients with acute myocardial infarction. Diagn Pathol，2014，9：89.

［35］Jayawardena TM，Egemnazarov B，Finch EA，et al. MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res，2012，110（11）：1465-1473.

［36］Care A，Catalucci D，Felicetti F，et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med，2007，13（5）：613-618.

［37］Meder B，Keller A，Vogel B，et al. MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol，2011，106（1）：13-23.

［38］Long G，Wang F，Duan Q，et al. Circulating miR-30a，miR-195 and let-7b associated with acute myocardial infarction. PLoS One，2012，7（12）：e50926.

［39］Marchand A，Proust C，Morange PE，et al. miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells. PLoS One，2012，7（8）：e44532.

［40］Xin M，Small EM，Sutherland LB，et al. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev，2009，23（18）：2166-2178.

［41］Adammek M，Greve B，Kässens N，et al. MicroRNA miR-145 inhibits proliferation，invasiveness，and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. Fertil Steril，2013，99（5）：1346-1355 e5.

［42］Adachi T，Nakanishi M，Otsuka Y，et al. Plasma microRNA 499 as a biomarker of acute myocardial infarction. Clin Chem，2010，56（7）：1183-1185.

［43］Wang J，Jia Z，Zhang C，et al. miR-499 protects cardiomyocytes from H ₂O ₂-induced apoptosis via its effects on Pdcd4 and Pacs2. RNA Biol，2014，11（4）：339-350.

［44］Tony H，Meng K，Wu B，et al. MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Mediators Inflamm，2015，2015：479123.

［45］Nabialek E，Wańha W，Kula D，et al. Circulating microRNAs（miR-423-5p，miR-208a and miR-1）in acute myocardial infarction and stable coronary heart disease. Minerva Cardioangiol，2013，61（6）：627-637.

［46］Zhong J，He Y，Chen W，et al. Circulating microRNA-19a as a potential novel biomarker for diagnosis of acute myocardial infarction. Int J Mol Sci，2014，15（11）：20355-20364.

［47］Qin X，Wang X，Wang Y，et al. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci USA，2010，107（7）：3240-3244.

［48］Li Z，Lu J，Luo Y，et al. High association between human circulating microRNA-497 and acute myocardial infarction. Scientific World Journal，2014，2014：931845.

［49］Kondkar AA，Abu-AmeroKK. Utility of circulating microRNAs as clinical biomarkers for cardiovascular diseases. Biomed Res Int，2015，2015：821823.

［50］Long G，Wang F，Duan Q，et al. Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. Int J Biol Sci，2012，8（6）：811-818.

［51］Liu K，Ying Z，Qi X，et al. MicroRNA-1 regulates the proliferation of vascular smooth muscle cells by targeting insulin-like growth factor 1. Int J Mol Med，2015，36（3）：817-824.

［52］Shi B，Guo Y，Wang J，et al. Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction. BMC Cardiovasc Disord，2010，10：11.

［53］Wang S，Aurora AB，Johnson BA，et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell，2008，15（2）：261-271.

［54］Boon RA，Dimmeler S. MicroRNAs in myocardial infarction. Nat Rev Cardiol，2015，12（3）：135-142.

［55］Zidar N，Boštjančič E，Glavač D，et al. MicroRNAs，innate immunity and ventricular rupture in human myocardial infarction. Dis Markers，2011，31（5）：259-265.

［56］Hou J，Wang P，Lin L，et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type Ⅰ IFN production in macrophages by targeting TRAF6，IRAK1，and IRAK2. J Immunol，2009，183（3）：2150-2158.

［57］Tolonen AM，Magga J，Szabó Z，et al. Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice. Pharmacol Res Perspect，2014，2（4）：e00056.

［58］Maurel M，Dejeans N，Taouji S，et al. MicroRNA-1291-mediated silencing of IRE1alpha enhances Glypican-3 expression. RNA，2013，19（6）：778-788.

［59］Lu HQ，Liang C，He ZQ，et al. Circulating miR-214 is associated with the severity of coronary artery disease. J Geriatr Cardiol，2013，10（1）：34-38.

［60］Matsumoto S，Sakata Y，Suna S，et al. Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circ Res，2013，113（3）：322-326.

［61］Corsten MF，Dennert R，Jochems S，et al. Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet，2010，3（6）：499-506.

［62］Matkovich SJ，Hu Y，Eschenbacher WH，et al. Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy. Circ Res，2012，111（5）：521-531.

［63］Tijsen AJ，Creemers EE，Moerland PD，et al. MiR423-5p as a circulating biomarker for heart failure. Circ Res，2010，106（6）：1035-1039.

［64］Goren Y，Kushnir M，Zafrir B，et al. Serum levels of microRNAs in patients with heart failure. Eur J Heart Fail，2012，14（2）：147-154.

［65］Marques FZ，Vizi D，Khammy O，et al. The transcardiac gradient of cardio-microRNAs in the failing heart. Eur J Heart Fail，2016，18（8）：1000-1008.

［66］Hong Y，Cao H，Wang Q，et al. MiR-22 may Suppress Fibrogenesis by Targeting TGFbetaR I in Cardiac Fibroblasts. Cell Physiol Biochem，2016，40（6）：1345-1353.

［67］Dickinson BA，Semus HM，Montgomery RL，et al. Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure. Eur J Heart Fail，2013，15（6）：650-659.

［68］Ke ZP，Xu P，Shi Y，et al. MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN. Oncotarget，2016，7（20）：28796-28805.

［69］Shi L，Kojonazarov B，Elgheznawy A，et al. miR-223-IGF-IR signalling in hypoxia-and load-induced right-ventricular failure：a novel therapeutic approach. Cardiovasc Res，2016，111（3）：184-193.

［70］Zhang H，Liu L，Hu J，et al. MicroRNA Regulatory Network Revealing the Mechanism of Inflammation in Atrial Fibrillation. Med Sci Monit，2015，21：3505-3513.

［71］Li H，Fan J，Yin Z，et al. Identification of cardiac-related circulating microRNA profile in human chronic heart failure. Oncotarget，2016，7（1）：33-45.

［72］Meng S，Cao J，Wang L，et al. MicroRNA 107 partly inhibits endothelial progenitor cells differentiation via HIF-1beta. PLoS One，2012，7（7）：e40323.

［73］Bronze-da-Rocha E. MicroRNAs expression profiles in cardiovascular diseases. Biomed Res Int，2014，2014：985408.

［74］Qiang L，Hong L，Ningfu W，et al. Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients. Int J Cardiol，2013，168（3）：2082-2088.

［75］Ellis KL，Cameron VA，Troughton RW，et al. Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. Eur J Heart Fail，2013，15（10）：1138-1147.

［76］Fang L，Ellims AH，Moore XL，et al. Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy. J Transl Med，2015，13：314.

［77］Tijsen AJ，van der Made I，van den Hoogenhof MM，et al. The microRNA-15 family inhibits the TGFbeta-pathway in the heart. Cardiovasc Res，2014，104（1）：61-71.

［78］Thome JG，Mendoza MR，Cheuiche AV，et al. Circulating microRNAs in obese and lean heart failure patients：A case-control study with computational target prediction analysis. Gene，2015，574（1）：1-10.

［79］Mohnle P，Schutz SV，Schmidt M，et al. MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure. Biochem Biophys Res Commun，2014，451（4）：516-521.

［80］Zhu H，Fan GC. Extracellular/circulating microRNAs and their potential role in cardiovascular disease. Am J Cardiovasc Dis，2011，1（2）：138-149.

［81］Weber M，Baker MB，Patel RS，et al. MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB. Cardiol Res Pract，2011，2011：532915.

［82］Hulsmans M，Sinnaeve P，Van der Schueren B，et al. Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease. J Clin Endocrinol Metab，2012，97（7）：1213-1218.

［83］Sun Y，Gao Y，Sun J，et al. Expression profile analysis based on DNA microarray for patients undergoing off-pump coronary artery bypass surgery. Exp Ther Med，2016，11（3）：864-872.

［84］Fang J，Song XW，Tian J，et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. Apoptosis，2012，17（4）：410-423.

［85］Khanaghaei M，Tourkianvalashani F，Hekmatimoghaddam S，et al. Circulating miR-126 and miR-499 reflect progression of cardiovascular disease；correlations with uric acid and ejection fraction. Heart Int，2016，11（1）：e1-e9.

［86］Takahashi Y，Satoh M，Minami Y，et al. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease：effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin Sci（Lond），2010，119（9）：395-405.

［87］Chen JJ，Zhou SH. Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway. Cardiol J，2011，18（6）：675-681.

［88］Hoekstra M，van der Lans CA，Halvorsen B，et al. The peripheral blood mononuclear cell microRNA signature of coronary artery disease. Biochem Biophys Res Commun，2010，394（3）：792-797.

［89］Derda AA，Thum S，Lorenzen JM，et al. Blood-based microRNA signatures differentiate various forms of cardiac hypertrophy. Int J Cardiol，2015，196：115-122.

［90］Nair N，Kumar S，Gongora E，et al. Circulating miRNA as novel markers for diastolic dysfunction. Mol Cell Biochem，2013，376（1-2）：33-40.

［91］Chavali V，Tyagi SC，Mishra PK. Differential expression of dicer，miRNAs，and inflammatory markers in diabetic Ins2﹢/-Akita hearts. Cell Biochem Biophys，2014，68（1）：25-35.

［92］McManus DD，Ambros V. Circulating MicroRNAs in cardiovascular disease. Circulation，2011，124（18）：1908-1910.

［93］Yu L，Yu H，Li X，et al. P38 MAPK/miR-1 are involved in the protective effect of EGCG in high glucose-induced Cx43 downregulation in neonatal rat cardiomyocytes. Cell Biol Int，2016，40（8）：934-942.

［94］Yu H，Lu Y，Li Z，et al. microRNA-133：expression，function and therapeutic potential in muscle diseases and cancer. Curr Drug Targets，2014，15（9）：817-828.

［95］Oliveira-Carvalho V，Carvalho VO，Bocchi EA. The emerging role of miR-208a in the heart. DNA Cell Biol，2013，32（1）：8-12.

［96］Doka G，Radik M，Krenek P，et al. 1A. 02：Microrna-208a And Its Host Gene Cardiac Myosin Heavy Chain Myh6 Are Involved In Hypertrophic Heart Dysfunction. J Hypertens，2015，33 Suppl 1：e1.

［97］McManus DD，Lin H，Tanriverdi K，et al. Relations between circulating microRNAs and atrial fibrillation：data from the Framingham Offspring Study. Heart Rhythm，2014，11（4）：663-669.

［98］Fujii T，Shimada K，Asano A，et al. MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. Int J Mol Sci，2016，17（8）：1351.

［99］Lu Y，Hou S，Huang D，et al. Expression profile analysis of circulating microRNAs and their effects on ion channels in Chinese atrial fibrillation patients. Int J Clin Exp Med，2015，8（1）：845-853.

［100］McManus DD，Tanriverdi K，Lin H，et al. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation（the miRhythm study）. Heart Rhythm，2015，12（1）：3-10.

［101］Liu S，Li W，Xu M，et al. Micro-RNA 21Targets dual specific phosphatase 8 to promote collagen synthesis in high glucosetreated primary cardiac fibroblasts. Can J Cardiol，2014，30（12）：1689-1699.

［102］Wei C，Henderson H，Spradley C，et al. Circulating miRNAs as potential marker for pulmonary hypertension. PLoS One，2013，8（5）：e64396.

［103］Creemers EE，Tijsen AJ，Pinto YM. Circulating microRNAs：novel biomarkers and extracellular communicators in cardiovascular disease？Circ Res，2012，110（3）：483-495.

［104］Mao J，Li C，Zhang Y，et al. Human with-no-lysine kinase-4 3′-UTR acting as the enhancer and being targeted by miR-296. Int J Biochem Cell Biol，2010，42（9）：1536-1543.

［105］Sayed AS，Xia K，Salma U，et al. Diagnosis，prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases. Heart Lung Circ，2014，23（6）：503-510.

［106］Huang Y，Tang S，Ji-Yan C，et al. Circulating miR-92a expression level in patients with essential hypertension：a potential marker of atherosclerosis. J Hum Hypertens，2017，31（3）：200-205.

［107］Mohsenin V. The emerging role of microRNAs in hypoxia-induced pulmonary hypertension. Sleep Breath，2016，20（3）：1059-1067.

［108］Romaine SP，Charchar FJ，Samani NJ，et al. Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk. Curr Opin Pharmacol，2016，27：1-7.

［109］Chen T，Zhou G，Zhou Q，et al. Loss of microRNA-17 approximately 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med，2015，191（6）：678-692.

［110］Sarrion I，Milian L，Juan G，et al. Role of circulating miRNAs as biomarkers in idiopathic pulmonary arterial hypertension：possible relevance of miR-23a. Oxid Med Cell Longev，2015，2015：792846.

［111］Yang Z，Kaye DM. Mechanistic insights into the link between a polymorphism of the 3′UTR of the SLC7A1 gene and hypertension. Hum Mutat，2009，30（3）：328-333.

［112］Wu WH，Hu CP，Chen XP，et al. MicroRNA-130a mediates proliferation of vascular smooth muscle cells in hypertension. Am J Hypertens，2011，24（10）：1087-1093.

［113］Sun HX，Zeng DY，Li RT，et al. Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension，2012，60（6）：1407-1414.

［114］Sang HY，Jin YL，Zhang WQ，et al. Downregulation of microRNA-637 Increases Risk of Hypoxia-Induced Pulmonary Hypertension by Modulating Expression of Cyclin Dependent Kinase 6（CDK6）in Pulmonary Smooth Muscle Cells. Med Sci Monit，2016，22：4066-4072.

［115］Chen W，Cai F，Zhang B，et al. The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer：potential biomarkers. Tumour Biol，2013，34（1）：455-462.

［116］Chen ZH，Zhang GL，Li HR，et al. A panel of five circulating microRNAs as potential biomarkers for prostate cancer. Prostate，2012，72（13）：1443-1452.

［117］Mahn R，Heukamp LC，Rogenhofer S，et al. Circulating microRNAs（miRNA）in serum of patients with prostate cancer. Urology，2011，77（5）：1265.

［118］Zhang HL，Yang LF，Zhu Y，et al. Serum miRNA-21：elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy. Prostate，2011，71（3）：326-331.

［119］Ling XH，Chen ZY，Luo HW，et al. BCL9，a coactivator for Wnt/beta-catenin transcription，is targeted by miR-30c and is associated with prostate cancer progression. Oncol Lett，2016，11（3）：2001-2008.

［120］Nguyen HC，Xie W，Yang M，et al. Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk，localized prostate cancer. Prostate，2013，73（4）：346-354.

［121］王琛，欧阳永日，路蔓，等.miR-141-3p靶向调控前列腺癌LNCaP细胞雄激素受体的表达.细胞与分子免疫学杂志，2015，31（6）：736-739.

［122］Zhang X，Tao T，Liu C，et al. Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1. Oncol Rep，2016，36（1）：376-382.

［123］Liu C，Guan H，Wang Y，et al. miR-195 Inhibits EMT by Targeting FGF2 in Prostate Cancer Cells. PLoS One，2015，10（12）：e0144073.

［124］Roth C，Rack B，Muller V，et al. Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res，2010，12（6）：R90.

［125］Mar-Aguilar F，Rodriguez-Oadilla C，Resendez-Perez D，et al. Serum circulating microRNA profiling for identification of potential breast cancer biomarkers. Dis Markers，2013，34（3）：163-169.

［126］Bourguignon LY，Spwvak CC，Wong G，et al. Hyaluronan-CD44 interaction with protein kinase C（epsilon）promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21，leading to down-regulation of the tumor suppressor protein PDCD4，anti-apoptosis，and chemotherapy resistance in breast tumor cells. J Biol Chem，2009，284（39）：26533-26546.

［127］Li L，Yuan L，Luo J，et al. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. Clin Exp Med，2013，13（2）：109-117.

［128］Si H，Sun X，Chen Y，et al. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer. J Cancer Res Clin Oncol，2013，139（2）：223-229.

［129］Wang M，Gu H，Wang S，et al. Circulating miR-17-5p and miR-20a：molecular markers for gastric cancer. Mol Med Rep，2012，5（6）：1514-1520.

［130］Zhang Y，Yan LX，Wu QN，et al. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 protooncogene in human invasive breast cancer. Cancer Res，2011，71（10）：3552-3562.

［131］Abedi N，Mohammadi-Yeganeh S，Koochaki A，et al. miR-141 as potential suppressor of beta-catenin in breast cancer. Tumour Biol，2015，36（12）：9895-9901.

［132］Madhavan D，Peng C，Wallwiener M，et al. Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer. Clin Cancer Res，2012，18（21）：5972-5982.

［133］Spizzo R，Nicoloso MS，Lupini L，et al. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ，2010，17（2）：246-254.

［134］Chan M，Liaw CS，Ji SM，et al. Identification of circulating microRNA signatures for breast cancer detection. Clin Cancer Res，2013，19（16）：4477-4487.

［135］Cuk K，Zucknick M，Madhavan D，et al. Circulating microRNAs in plasma as early detection markers for breast cancer. Int J Cancer，2013，132（7）：1602-1612.

［136］Cimino D，De Pitta C，Orso F，et al. miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5，ROCK1，PIK3CA，NRAS，and CSF1. FASEB J，2013，27（3）：1223-1235.

［137］Ming J，Zhou Y，Du J，et al. Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells. Biosci Rep，2015，35（5）：e00251.

［138］Hong H，Yu H，Yuan J，et al. MicroRNA-200b Impacts Breast Cancer Cell Migration and Invasion by Regulating Ezrin-Radixin-Moesin. Med Sci Monit，2016，22：1946-1952.

［139］Madhavan D，Peng C，Wallwiener M，et al. Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis，2016，37（5）：461-470.

［140］Song C，Liu LZ，Pei XQ，et al. miR-200c inhibits breast cancer proliferation by targeting KRAS. Oncotarget，2015，6（33）：34968-34978.

［141］He S，Zhang G，Dong H，et al. miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer. Onco Targets Ther，2016，9：6203-6210.

［142］Liu D，Xia H，Wang F，et al. MicroRNA-210 interacts with FBXO31 to regulate cancer proliferation cell cycle and migration in human breast cancer. Onco Targets Ther，2016，9：5245-5255.

［143］van Schooneveld E，Wouters MC，Van der Auwera I，et al. Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with（metastatic）breast cancer and healthy volunteers. Breast Cancer Res，2012，14（1）：R34.

［144］Ge G，Zhang W，Niu L，et al. miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis. Oncol Rep，2016，35（3）：1816-1822.

［145］Shevde LA，Metge BJ，Mitra A，et al. Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin. J Cell Mol Med，2010，14（6B）：1693-1706.

［146］Ding W，Fan XL，Xu X，et al. Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. PLoS One，2015，10（8）：e0135128.

［147］Di Leva G，Piovan C，Gasparini P，et al. Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet，2013，9（3）：e1003311.

［148］Liu SL，Sui YF，Lin MZ. MiR-375 is epigenetically downregulated due to promoter methylation and modulates multi-drug resistance in breast cancer cells via targeting YBX1. Eur Rev Med Pharmacol Sci，2016，20（15）：3223-3229.

［149］Ho JY，Hsu RJ，Liu JM，et al. MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. Oncotarget，2017，8（14）：22443-22459.

［150］Ma Z，Li Y，Xu J，et al. MicroRNA-409-3p regulates cell invasion and metastasis by targeting ZEB1 in breast cancer. IUBMB Life，2016，68（5）：394-402.

［151］Zhang Y，Xu G，Liu G，et al. miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2. Biochem Biophys Res Commun，2016，476（4）：607-613.

［152］Ng EK，Li R，Shin VY，et al. Circulating microRNAs as specific biomarkers for breast cancer detection. PLoS One，2013，8（1）：e53141.

［153］Jurkovicova D，Magyerkova M，Sestakova Z，et al. Evaluation of expression profiles of microRNAs and two target genes，FOXO3a and RUNX2，effectively supports diagnostics and therapy predictions in breast cancer. Neoplasma，2016，63（6）：941-951.

［154］Heneghan HM，Miller N，Lowery AJ，et al. Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg，2010，251（3）：499-505.

［155］Singh R，Yadav V，Kumar S，et al. MicroRNA-195 inhibits proliferation，invasion and metastasis in breast cancer cells by targeting FASN，HMGCR，ACACA and CYP27B1. Sci Rep，2015，5：17454.

［156］Wu Q，Lu Z，Li H，et al. Next-generation sequencing of microRNAs for breast cancer detection. J Biomed Biotechnol，2011，2011：597145.

［157］Pei YF，Lei Y，Liu XQ. MiR-29a promotes cell proliferation and EMT in breast cancer by targeting ten eleven translocation 1. Biochim Biophys Acta，2016，1862（11）：2177-2185.

［158］Hu Z，Dong J，Wang LE，et al. Serum microRNA profiling and breast cancer risk：the use of miR-484/191 as endogenous controls. Carcinogenesis，2012，33（4）：828-834.

［159］Venturutti L，Cordo Russo RI，Rivas MA，et al. MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. Oncogene，2016，35（48）：6189-6202.

［160］Wang Z，Wang N，Liu P，et al. MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells，a process modulated by the natural autophagy inducer isoliquiritigenin. Oncotarget，2014，5（16）：7013-7026.

［161］Wang DD，Li J，Sha HH，et al. miR-222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27（kip1）expression. Gene，2016，590（1）：44-50.

［162］Joosse SA，Muller V，Steinbach B，et al. Circulating cell-free cancer-testis MAGE-A RNA，BORIS RNA，let-7b and miR-202 in the blood of patients with breast cancer and benign breast diseases. Br J Cancer，2014，111（5）：909-917.

［163］Fonseca-Sanchez MA，Perez-Plasencia C，Fernandez-Retana J，et al. microRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration. Oncol Rep，2013，30（5）：2399-2410.

［164］Hu Z，Chen X，Zhao Y，et al. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol，2010，28（10）：1721-1726.

［165］Yu QQ，Wu H，Huang X，et al. MiR-1 targets PIK3CA and inhibits tumorigenic properties of A549 cells. Biomed Pharmacother，2014，68（2）：155-161.

［166］Boeri M，Verri C，Conte D，et al. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci USA，2011，108（9）：3713-3718.

［167］Zhao Z，Zhang L，Yao Q，et al，miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells. Cancer Gene Ther，2015，22（3）：108-114.

［168］Zhao Z，Zhang L，Yao Q，et al. Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis. RNA Biol，2011，8（3）：506-516.

［169］Chatterjee A，Chattopadhyay D，Chakrabarti G. MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis. Cell Signal，2015，27（2）：189-203.

［170］Chatterjee A，Chattopadhyay D，Chakrabarti G. miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression. PLoS One，2014，9（4）：e95716.

［171］Heegaard NH，Schetter AJ，Welsh JA，et al. Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int J Cancer，2012，130（6）：1378-1386.

［172］Li J，Wang Y，Song Y，et al. miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells. Mol Cancer，2014，13：193.

［173］Wang H，Zhu Y，Zhao M，et al. miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin beta1 and matrix metalloproteinase2（MMP2）. PLoS One，2013，8（8）：e70192.

［174］Zheng D，Haddadin S，Wang Y，et al. Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol，2011，4（6）：575-586.

［175］Xue X，Liu Y，Wang Y，et al. MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1，SOCS6，and PTEN. Oncotarget，2016，7（51）：84508-84519.

［176］Wang M，Wang Y，Zang W，et al. Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol，2014，35（1）：39-46.

［177］Dubey R，Saini N. STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells. Biochim Biophys Acta，2015，1849（1）：32-43.

［178］Liu XG，Zhu WY，Huang YY，et al. High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer. Med Oncol，2012，29（2）：618-626.

［179］Shi L，Zhang S，Wu H，et al. MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway. PLoS One，2013，8（10）：e78344.

［180］Shen J，Todd NW，Zhang H，et al. Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest，2011，91（4）：579-587.

［181］Puisségur MP，Mazure NM，Bertero T，et al. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ，2011，18（3）：465-478.

［182］Zhang C，Zhang J，Zhang A，et al. PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol，2010，37（6）：1621-1626.

［183］Chen D，Huang J，Zhang K，et al. MicroRNA-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung adenocarcinoma cells by targeting proto-oncogene c-Myc. Eur J Cancer，2014，50（17）：3050-3067.

［184］He Z，Xia Y，Pan C，et al. Up-Regulation of MiR-452 Inhibits Metastasis of Non-Small Cell Lung Cancer by Regulating BMI1. Cell Physiol Biochem，2015，37（1）：387-398.

［185］Foss KM，Sima C，Ugolini D，et al. miR-1254 and miR-574-5p：serum-based microRNA biomarkers for early-stage non-small cell lung cancer. J Thorac Oncol，2011，6（3）：482-488.

［186］Li Q，Li X，Guo Z，et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. PLoS One，2012，7（11）：e48278.

［187］Lin Y，Zhao J，Hu X，et al. Transcription factor CCAAT/enhancer binding protein alpha up-regulates microRNA let-7a-1 in lung cancer cells by direct binding. Cancer Cell Int，2016，16：17.

［188］Dou H，Wang Y，Su G，et al. Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer. Int J Clin Exp Med，2015，8（6）：9291-9298.

［189］Zhao B，Han H，Chen J，et al. MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. Cancer Lett，2014，342（1）：43-51.

［190］Tang D，Shen Y，Wang M，et al. Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer. Eur J Cancer Prev，2013，22（6）：540-548.

［191］Wu YL，Hsu NY，Cheau-Feng Lin F，et al. MiR-30c-2 ^*negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer. Surgery，2016，160（6）：1591-1598.

［192］Chen D，Guo W，Qiu Z，et al. MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer. Cancer Lett，2015，362（2）：208-217.

［193］Xie X，Liu HT，Mei J，et al. miR-106a promotes growth and metastasis of non-small cell lung cancer by targeting PTEN. Int J Clin Exp Pathol，2015，8（4）：3827-3834.

［194］Song L，Li D，Gu Y，et al. MicroRNA-126 Targeting PIK3R2 Inhibits NSCLC A549 Cell Proliferation，Migration，and Invasion by Regulation of PTEN/PI3K/AKT Pathway. Clin Lung Cancer，2016，17（5）：e65-e75.

［195］Li W，He F. Monocyte to macrophage differentiation-associated（MMD）targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer. Biochem Biophys Res Commun，2014，450（1）：844-850.

［196］Wang D，Ma J，Ji X，et al. miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncol Rep，2017，37（1）：608-616.

［197］Nadal E，Truini A，Nakata A，et al. A Novel Serum 4-microRNA Signature for Lung Cancer Detection. Sci Rep，2015，5：12464.

［198］Lei Z，Xu G，Wang L，et al. MiR-142-3p represses TGF-beta-induced growth inhibition through repression of TGFbetaR1 in non-small cell lung cancer. FASEB J，2014，28（6）：2696-2704.

［199］Mataki H，Seki N，Mizuno K，et al. Dual-strand tumor-suppressor microRNA-145（miR-145-5p and miR-145-3p）coordinately targeted MTDH in lung squamous cell carcinoma. Oncotarget，2016，7（44）：72084-72098.

［200］Lai X，Friedman A. Exosomal miRs in Lung Cancer：A Mathematical Model. PLoS One，2016，11（12）：e0167706.

［201］Chen X，Ba Y，Ma L，et al. Characterization of microRNAs in serum：a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res，2008，18（10）：997-1006.

［202］Zhang YJ，Liu XC，Du J，et al. MiR-152 regulates metastases of non-small cell lung cancer cells by targeting neuropilin-1. Int J Clin Exp Pathol，2015，8（11）：14235-14240.

［203］Cheng Z，Ma R，Tan W，et al. MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2. Exp Mol Med，2014，46：e112.

［204］Fan L，Qi H，Teng J，et al. Identification of serum miRNAs by nano-quantum dots microarray as diagnostic biomarkers for early detection of non-small cell lung cancer. Tumour Biol，2016，37（6）：7777-7784.

［205］Chen X，Wang X，He H，et al. Combination of circulating tumor cells with serum carcinoembryonic antigen enhances clinical prediction of non-small cell lung cancer. PLoS One，2015，10（5）：e0126276.

［206］Liu M，Zhou K，Cao Y. MicroRNA-944 Affects Cell Growth by Targeting EPHA7 in Non-Small Cell Lung Cancer. Int J Mol Sci，2016，17（10）.

［207］Powrózek T，Krawczyk P，Kowalski DM，et al. Plasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers. Transl Res，2015，166（4）：315-323.

［208］Song Q，Xu Y，Yang C，et al. miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res，2014，74（11）：3031-3042.

［209］Wang C，Ding M，Xia M，et al. A Five-miRNA Panel Identified From a Multicentric Case-control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer Patients. EBioMedicine，2015，2（10）：1377-1385.

［210］Xiang J，Hang JB，Che JM，et al. MiR-25 is up-regulated in non-small cell lung cancer and promotes cell proliferation and motility by targeting FBXW7. Int J Clin Exp Pathol，2015，8（8）：9147-9153.

［211］Chen Z，Wu Y，Meng Q，et al. Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3. In Vitro Cell Dev Biol Anim，2016，52（1）：62-67.

［212］Zhao X，Lu C，Chu W，et al. microRNA-214 Governs Lung Cancer Growth and Metastasis by Targeting Carboxypeptidase-D. DNA Cell Biol，2016，35（11）：715-721.

［213］Zhao JG，Men WF，Tang J. MicroRNA-7 enhances cytotoxicity induced by gefitinib in non-small cell lung cancer via inhibiting the EGFR and IGF1R signalling pathways. Contemp Oncol（Pozn），2015，19（3）：201-206.

［214］Wang RJ，Zheng YH，Wang P，et al. Serum miR-125a-5p，miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer. Int J Clin Exp Pathol，2015，8（1）：765-771.

［215］H Halvorsen AR，Bjaanæs M，LeBlanc M，et al. A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer. Oncotarget，2016，7（24）：37250-37259.

［216］Xiao P，Liu W，Zhou H. miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1. Oncol Lett，2016，12（3）：2163-2168.

［217］Kim JS，Kurie JM，Ahn YH. BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells. Mol Cancer，2015，14：173.

［218］H Hu，Z Xu，C Li，et al. MiR-145 and miR-203 represses TGF-beta-induced epithelial-mesenchymal transition and invasion by inhibiting SMAD3 in non-small cell lung cancer cells. Lung Cancer，2016，97：87-94.

［219］Y Li，Y Chao，Y Fang，et al. MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. J Exp Clin Cancer Res，2013，32：33.

［220］Ng EK，Chong WW，Jin H，et al. Differential expression of microRNAs in plasma of patients with colorectal cancer：a potential marker for colorectal cancer screening. Gut，2009，58（10）：1375-1381.

［221］MD Giráldez，JJ Lozano，G Ramírez，et al. Circulating microRNAs as biomarkers of colorectal cancer：results from a genomewide profiling and validation study. Clin Gastroenterol Hepatol，2013，11（6）：681-688. e3.

［222］G Yu，X Wang，T Wu，et al. MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem，2013，380（1-2）：239-247.

［223］Z Huang，D Huang，S Ni，et al. Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int J Cancer，2010，127（1）：118-126.

［224］G Zhang，H Zhou，H Xiao，et al. MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN. Dig Dis Sci，2014，59（1）：98-107.

［225］H Cheng，L Zhang，DE Cogdell，et al. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One，2011，6（3）：e17745.

［226］L Feng，H Ma，L Chang，et al. Role of microRNA-141 in colorectal cancer with lymph node metastasis. Exp Ther Med，2016，12（5）：3405-3410.

［227］Soo Young Kim，Young-Hoon Lee，Young-Seuk Bae. MiR-186，miR-216b，miR-337-3p，and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells. Biochem Biophys Res Commun，2012，429（3-4）：173-179.

［228］X Pu，G Huang，H Guo，et al. Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression. J Gastroenterol Hepatol，2010，25（10）：1674-1680.

［229］Qin J，Luo M. MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK. FEBS Lett，2014，588（1）：99-104.

［230］Humphreys KJ，McKinnon RA，Michael MZ. miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PLoS One，2014.9（11）：e112288.

［231］ZF Sun，Z Zhang，Z Liu，et al. MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2. Med Oncol，2014，31（6）：982.

［232］Z Kanaan，SN Rai，MR Eichenberger，et al. Plasma miR-21：a potential diagnostic marker of colorectal cancer. Ann Surg，2012，256（3）：544-551.

［233］W Tang，Y Zhu，J Gao，et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4. Br J Cancer，2014，110（2）：450-458.

［234］M Tsujiura，D Ichikawa，S Komatsu，et al. Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer，2010，102（7）：1174-1179.

［235］K Ohshima，K Inoue，A Fujiwara，et al. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One，2010，5（10）：e13247.

［236］Hossain A，MT Kuo，GF. Saunders. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol，2006，26（21）：8191-8201.

［237］Z Zhang，Z Li，C Gao，et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest，2008，88（12）：1358-1366.

［238］R Liu，C Zhang，Z Hu，et al. A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer，2011，47（5）：784-791.

［239］Q Sun，H Gu，Y Zeng，et al. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci，2010，101（10）：2241-2247.

［240］Q Ji，X Hao，Y Meng，et al. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer，2008，8：266.

［241］B Li，Y Zhao，G Guo，et al. Plasma microRNAs，miR-223，miR-21 and miR-218，as novel potential biomarkers for gastric cancer detection. PLoS One，2012，7（7）：e41629.

［242］J Tie，Y Pan，L Zhao，et al. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet，2010，6（3）：e1000879.

［243］X Li，Y Zhang，H Zhang，et al. miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res，2011，9（7）：824-833.

［244］M Song，K Pan，H Su，et al. Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One，2012，7（3）：e33608.

［245］G Ye，G Fu，S Cui，et al. MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7：implications for chemoresistance. J Cell Sci，2011，124（Pt 3）：359-368.

［246］H Liu，L Zhu，B Liu，et al. Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett，2012，316（2）：196-203.

［247］Fei B，H. Wu. MiR-378 inhibits progression of human gastric cancer MGC-803 cells by targeting MAPK1 in vitro. Oncol Res，2012，20（12）：557-564.

［248］J Liu，X Wang，X Yang，et al. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett，2014，347（1）：98-104.

［249］H Konishi，D Ichikawa，S Komatsu et al. Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre-and post-operative plasma. Br J Cancer，2012，106（4）：740-747.

［250］You W，Xu L，Zhang X，et al. High-Throughput Screening Identifies miR-451 as a Pleiotropic Modulator That Suppresses Gastric Cancer Metastasis. J Lab Autom，2016.

［251］C Li，JF Li，Q Cai，et al. miRNA-199a-3p in plasma as a potential diagnostic biomarker for gastric cancer. Ann Surg Oncol，2013，20 Suppl 3：S397-405.

［252］KW Hsu，WL Fang，KH Huang，et al. Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget，2016，7（25）：38036-38051.

［253］M Zhu，N Zhang，S He，et al. MicroRNA-106a functions as an oncogene in human gastric cancer and contributes to proliferation and metastasis in vitro and in vivo. Clin Exp Metastasis，2016，33（5）：509-519.

［254］Y Zhang，T Han，G Wei，et al. Inhibition of microRNA-17/20a suppresses cell proliferation in gastric cancer by modulating UBE2C expression. Oncol Rep，2015，33（5）：2529-2536.

［255］X Zhang，Y Kong，X Xu，et al. F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a. Oncotarget，2014，5（15）：6178-6190.

［256］ZX Su，J Zhao，ZH Rong，et al. Diagnostic and prognostic value of circulating miR-18a in the plasma of patients with gastric cancer. Tumour Biol，2014，35（12）：12119-12125.

［257］YJ Chen，H Wu，JM Zhu，et al. MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients. J Gastroenterol Hepatol，2016，31（1）：155-163.

［258］Z Wang，X Ma，Q Cai，et al. MiR-199a-3p promotes gastric cancer progression by targeting ZHX1. FEBS Lett，2014，588（23）：4504-4512.

［259］Y Du，M Zhu，X Zhou，et al. miR-20a enhances cisplatin resistance of human gastric cancer cell line by targeting NFKBIB. Tumour Biol，2016，37（1）：1261-1269.

［260］M Zhu，X Zhou，Y Du，et al. miR-20a induces cisplatin resistance of a human gastric cancer cell line via targeting CYLD. Mol Med Rep，2016，14（2）：1742-1750.

［261］Valladares-Ayerbes M，Reboredo M，Medina-Villaamil V，et al. Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer. J Transl Med，2012，10：186.

［262］W Zhu，H Xu，DX Zhu，et al. miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. Cancer Chemother Pharmacol，2012，69（3）：723-731.

［263］W Liu，N Song，H Yao，et al. miR-221 and miR-222 Simultaneously Target RECK and Regulate Growth and Invasion of Gastric Cancer Cells. Med Sci Monit，2015，21：2718-2725.

［264］Z Chun-zhi，H Lei，Z An-ling，et al. MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. BMC Cancer，2010，10：367.

［265］Z Fu，F Qian，X Yang，et al. Circulating miR-222 in plasma and its potential diagnostic and prognostic value in gastric cancer. Med Oncol，2014，31（9）：164.

［266］J Wu，G Li，Y Yao，et al. MicroRNA-421 is a new potential diagnosis biomarker with higher sensitivity and specificity than carcinoembryonic antigen and cancer antigen 125 in gastric cancer. Biomarkers，2015，20（1）：58-63.

［267］JH Wu，YL Yao，T Gu，et al. MiR-421 regulates apoptosis of BGC-823 gastric cancer cells by targeting caspase-3. Asian Pac J Cancer Prev，2014，15（13）：5463-5468.

［268］R Zhang，W Wang，F Li，et al. MicroRNA-106b ～25 expressions in tumor tissues and plasma of patients with gastric cancers. Med Oncol，2014，31（10）：243.

［269］J Xu，C Wu，X Che，et al. Circulating microRNAs，miR-21，miR-122，and miR-223，in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog，2011，50（2）：136-142.

［270］Z Ahsani，S Mohammadi-Yeganeh，V Kia，et al. WNT1 Gene from WNT Signaling Pathway Is a Direct Target of miR-122 in Hepatocellular Carcinoma. Appl Biochem Biotechnol，2017，181（3）：884-897.

［271］Z Dong，R Qi，X Guo，et al. MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation. Biochem Biophys Res Commun，2016，483（1）：630-637.

［272］D Yin，Y Wang，W Sai，et al. HBx-induced miR-21 suppresses cell apoptosis in hepatocellular carcinoma by targeting interleukin-12. Oncol Rep，2016，36（4）：2305-2312.

［273］Z Zhang，H Meng，N Wang，et al. Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma. Diagn Pathol，2014，9：135.

［274］Y Wang，Z Lu，Y Li，et al. miR-143 inhibits proliferation and invasion of hepatocellular carcinoma cells via down-regulation of TLR2 expression. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi，2014，30（10）：1076-1769.

［275］F Liu，X You，X Chi，et al. Hepatitis B virus X protein mutant HBxDelta127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochem Biophys Res Commun，2014，444（2）：128-134.

［276］L Jiang，Q Cheng，BH Zhang，et al. Circulating microRNAs as biomarkers in hepatocellular carcinoma screening：a validation set from China. Medicine（Baltimore），2015，94（10）：e603.

［277］Q Li，L Zhou，F Yang，et al. MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol，2012，33（5）：1455-1465.

［278］WL Yau，CSC Lam，L Ng，et al. Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process. PLoS One，2013，8（3）：e57882.

［279］J Azumi，T Tsubota，T Sakabe，et al. miR-181a induces sorafenib resistance of hepatocellular carcinoma cells through downregulation of RASSF1 expression. Cancer Sci，2016，107（9）：1256-1262.

［280］Y Tan，G Ge，T Pan，et al. A serum microRNA panel as potential biomarkers for hepatocellular carcinoma related with hepatitis B virus. PLoS One，2014，9（9）：e107986.

［281］W Liu，C Xu，H Wan，et al. MicroRNA-206 overexpression promotes apoptosis，induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells. Int J Mol Med，2014，34（2）：420-428.

［282］Q Shen，VR Cicinnati，X Zhang，et al. Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer，2010，9：227.

［283］Nassirpour R，PP Mehta，MJ Yin. miR-122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3. PLoS One，2013，8（11）：e79655.

［284］L Yan-Chun，Y Hong-Mei，C Zhi-Hong，et al. MicroRNA-192-5p Promote the Proliferation and Metastasis of Hepatocellular Carcinoma Cell by Targeting SEMA3A. Appl Immunohistochem Mol Morphol，2015.

［285］Chang L，K Li，T Guo. miR-26a-5p suppresses tumor metastasis by regulating EMT and is associated with prognosis in HCC. Clin Transl Oncol，2016，19（6）：695-703.

［286］J Zhou，L Yu，X Gao，et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol，2011，29（36）：4781-4788.

［287］J Lian，Y Jing，Q Dong，et al. miR-192，a prognostic indicator，targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget，2016，7（3）：2672-2683.

［288］KZ Qu，K Zhang，HR Li，et al. Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol，2011，45（4）：355-360.

［289］H Liang，Z Fu，X Jiang，et al. miR-16 promotes the apoptosis of human cancer cells by targeting FEAT. BMC Cancer，2015，15：448.

［290］J Yin，P Hou，Z Wu，et al. Circulating miR-375 and miR-199a-3p as potential biomarkers for the diagnosis of hepatocellular carcinoma. Tumour Biol，2015，36（6）：4501-4507.

［291］K Ren，T Li，W Zhang，et al. miR-199a-3p inhibits cell proliferation and induces apoptosis by targeting YAP1，suppressing Jagged1-Notch signaling in human hepatocellular carcinoma. J Biomed Sci，2016，23（1）：79.

［292］Z Oksuz，MS Serin，E Kaplan，et al. Serum microRNAs：miR-30c-5p，miR-223-3p，miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma. Mol Biol Rep，2015，42（3）：713-720.

［293］SW Shan，L Fang，T Shatseva，et al. Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN，GalNT7 and vimentin in different signal pathways. J Cell Sci，2013，126（Pt 6）：1517-1530.

［294］Köberle V，Kronenberger B，Pleli T，et al. Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. Eur J Cancer，2013，49（16）：3442-3449.

［295］Li D，Liu Y，Li H，et al. MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5（API-5）. FEBS Lett，2015，589（1）：68-76.

［296］Pritchard CC，Kroh E，Wood B，et al. Blood cell origin of circulating microRNAs：a cautionary note for cancer biomarker studies. Cancer Prev Res（Phila），2012，5（3）：492-497.

［297］Liu Z，Wang C，Jiao X，et al. miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NFkappaB. Am J Transl Res，2016，8（11）：4764-4777.

［298］Li L，Guo Z，Wang J，et al. Serum miR-18a：a potential marker for hepatitis B virus-related hepatocellular carcinoma screening. Dig Dis Sci，2012，57（11）：2910-2916.

［299］Li LM，Hu ZB，Zhou ZX，et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res，2010，70（23）：9798-9807.

［300］Wang C，Wang X，Su Z，et al. MiR-25 promotes hepatocellular carcinoma cell growth，migration and invasion by inhibiting RhoGDI1. Oncotarget，2015，6（34）：36231-36244.

［301］Shigoka M，Tsuchida A，Matsudo T，et al. Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int，2010，60（5）：351-357.

［302］Yang W，Dou C，Wang Y，et al. MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7. Oncol Rep，2015，34（5）：2576-2584.

［303］Liu AM，Yao TJ，Wang W，et al. Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma：a retrospective cohort study. BMJ Open，2012，2（2）：e000825.

［304］Xu T，Zhu Y，Xiong Y，et al. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology，2009，50（1）：113-121.

［305］Wang M，Zhang J，Tong L，et al. MiR-195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA. Int J Clin Exp Pathol，2015，8（11）：14110-14120.

［306］Galardi S，Mercatelli N，Giorda E，et al. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem，2007，282（32）：23716-23724.

［307］Yang YF，Wang F，Xiao JJ，et al. MiR-222 overexpression promotes proliferation of human hepatocellular carcinoma HepG2 cells by downregulating p27. Int J Clin Exp Med，2014，7（4）：893-902.

［308］Li Q，Ding C，Chen C，et al. miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma. J Gastroenterol Hepatol，2014，29（4）：835-842.

［309］Fiorino S，Bacchi-Reggiani ML，Visani M，et al. MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B-and C-related-hepatocellular-carcinoma. World J Gastroenterol，2016，22（15）：3907-3936.

［310］He XX，Chang Y，Meng FY，et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene，2012，31（28）：3357-3369.

［311］Ciafrè SA，Galardi S，Mangiola A，et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun，2005，334（4）：1351-1358.

［312］Afanasyeva EA，Mestdagh P，Kumps C，et al. MicroRNA miR-885-5p targets CDK2 and MCM5，activates p53 and inhibits proliferation and survival. Cell Death Differ，2011，18（6）：974-984.

［313］Zhang Z，Yin J，Yang J，et al. miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/beta-catenin signaling pathway. Oncotarget，2016，7（46）：75038-75051.

［314］Wang J，Chen J，Chang P，et al. MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res（Phila），2009，2（9）：807-813.

［315］Huang C，Li H，Wu W，et al. Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. Oncol Rep，2013，30（3）：1223-1230.

［316］Pan W，Tang W，Yuan W，et al. ，Expression and clinical significance of plasma small RNA in patients with pancreatic cancer. Zhonghua Zhong Liu Za Zhi，2014，36（5）：351-354.

［317］Wei X，Wang W，Wang L，et al. MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4. Cancer Med，2016，5（4）：693-702.

［318］Li A，Omura N，Hong SM，et al. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res，2010，70（13）：5226-5237.

［319］Soubani O，Ali AS，Logna F，et al. Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer. Carcinogenesis，2012，33（8）：1563-1571.

［320］Gui Z，Luo F，Yang Y1，et al. Oridonin inhibition and miR200b3p/ZEB1 axis in human pancreatic cancer. Int J Oncol，2017，50（1）：111-120.

［321］Morimura R，Komatsu S，Ichikawa D，et al. Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer. Br J Cancer，2011，105（11）：1733-1740.

［322］Liu J，Gao J，Du Y，et al. Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer. Int J Cancer，2012，131（3）：683-691.

［323］Shen J，Wan R，Hu G，et al. miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro. Pancreatology，2012，12（2）：91-99.

［324］Liu R，Chen X，Du Y，et al. Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem，2012，58（3）：610-618.

［325］Liu H，Xu XF，Zhao Y，et al. MicroRNA-191 promotes pancreatic cancer progression by targeting USP10. Tumour Biol，2014，35（12）：12157-12163.

［326］Yan H，Wu J，Liu W，et al. MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. Hum Gene Ther，2010，21（12）：1723-1734.

［327］Listing H，Mardin WA，Wohlfromm S，et al. MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer. Br J Cancer，2015，112（1）：131-139.

［328］Li A，Yu J，Kim H，et al. MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with lowstage pancreatic cancer from healthy and disease controls. Clin Cancer Res，2013，19（13）：3600-3610.

［329］Kawaguchi T，Komatsu S，Ichikawa D，et al. Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer. Br J Cancer，2013，108（2）：361-369.

［330］Sarkar S，Dubaybo H，Ali S，et al. Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN，p27（kip1），p57（kip2），and PUMA. Am J Cancer Res，2013，3（5）：465-477.

［331］Carlsen AL，Joergensen MT，Knudsen S，et al. Cell-free plasma microRNA in pancreatic ductal adenocarcinoma and disease controls. Pancreas，2013，42（7）：1107-1113.

［332］Zhou J，Song S，He S，et al. MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. Int J Mol Med，2014，33（4）：950-956.

［333］Wang WS，Liu LX，Li GP，et al. Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. Cancer Prev Res（Phila），2013，6（4）：331-338.

［334］Ganepola GA，Rutledge JR，Suman P，et al. Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer. World J Gastrointest Oncol，2014，6（1）：22-33.

［335］Abue M，Yokoyama M，Shibuya R，et al. Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol，2015，46（2）：539-547.

［336］Hao J，Zhang S，Zhou Y，et al. MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer. FEBS Lett，2011，585（1）：207-213.

［337］Adam L，Wszolek MF，Liu CG，et al. Plasma microRNA profiles for bladder cancer detection. Urol Oncol，2013，31（8）：1701-1708.

［338］Wang H，Ke C，Ma X，et al. MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3beta and activating Wnt signaling in bladder cancer cells. Tumour Biol，2016.

［339］Scheffer AR，Holdenrieder S，Kristiansen G，et al. Circulating microRNAs in serum：novel biomarkers for patients with bladder cancer？World J Urol，2014，32（2）：353-358.

［340］Fayyad-Kazan H，Bitar N，Najar M，et al. Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemia. J Transl Med，2013，11：31.

［341］Fang ZH，Wang SL，Zhao JT，et al. miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways. Cell Death Dis，2016，7（9）：e2371.

［342］Tang X，Chen L，Yan X，et al. Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia. Med Sci Monit，2015，21：3427-3433.

［343］Wang Z，Hong Z，Gao F，et al. Upregulation of microRNA-375 is associated with poor prognosis in pediatric acute myeloid leukemia. Mol Cell Biochem，2013，383（1-2）：59-65.

［344］Xiao Y，C Su，T Deng. miR-223 decreases cell proliferation and enhances cell apoptosis in acute myeloid leukemia via targeting FBXW7. Oncol Lett，2016，12（5）：3531-3536.

［345］Zou ZJ，Fan L，Wang，et al. miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia，but not PTEN mutation or promoter methylation. Oncotarget，2015，6（2）：1276-1285.

［346］Liu L，Chen R，Zhang Y，et al. Low expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia. Diagn Pathol，2015，10：109.

［347］Kato M，Zhang J，Wang M，et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci USA，2007，104（9）：3432-3437.

［348］Hanke M，Hoefig K，Merz H，et al. A robust methodology to study urine microRNA as tumor marker：microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol，2010，28（6）：655-661.

［349］Zhang J，Du YY，Lin YF，et al. The cell growth suppressor，mir-126，targets IRS-1. Biochem Biophys Res Commun，2008，377（1）：136-140.

［350］Yu J，Lei R，Zhuang X，et al. MicroRNA-182 targets SMAD7 to potentiate TGFbeta-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun，2016，7：13884.

［351］Miah S，Dudziec E，Drayton RM，et al. An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer. Br J Cancer，2012，107（1）：123-128.

［352］Wang Y，Wang M，Wei W，et al. Disruption of the EZH2/miRNA/beta-catenin signaling suppresses aerobic glycolysis in glioma. Oncotarget，2016，7（31）：49450-49458.

［353］Zhang X，Zhang Y，Liu X，et al. Direct quantitative detection for cell-free miR-155 in urine：a potential role in diagnosis and prognosis for non-muscle invasive bladder cancer. Oncotarget，2016，7（3）：3255-3266.

［354］Peng Y，Dong W，Lin TX，et al. MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1. Oncotarget，2015，6（18）：16043-16058.

［355］Wang J，Zhang X，Wang L，et al. MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. PLoS One，2015，10（2）：e0118086.

［356］Wang J，Zhang X，Wang L，et al. Downregulation of urinary cell-free microRNA-214 as a diagnostic and prognostic biomarker in bladder cancer. J Surg Oncol，2015，111（8）：992-999.

［357］Eissa S，Habib H，Ali E，et al. Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis. Med Oncol，2015，32（1）：413.

［358］Wang Y，Luo H，Li Y，et al. ，hsa-miR-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas. Mol Med Rep，2012，5（1）：260-265.

［359］Liu L，Qiu M，Tan G，et al. miR-200c inhibits invasion，migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3. J Transl Med，2014，12：305.

［360］Park SM，Gaur AB，Lengyel E，et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev，2008，22（7）：894-907.

［361］Wang G，Chan ES，Kwan BC，et al. Expression of microRNAs in the urine of patients with bladder cancer. Clin Genitourin Cancer，2012，10（2）：106-113.

［362］Shan Q，Zheng G，Zhu A，et al. Epigenetic modification of miR-10a regulates renal damage by targeting CREB1 in type 2 diabetes mellitus. Toxicol Appl Pharmacol，2016，306：134-143.

［363］Wang N，Zhou Y，Jiang L，et al. Urinary microRNA-10a and microRNA-30d serve as novel，sensitive and specific biomarkers for kidney injury. PLoS One，2012，7（12）：e51140.

［364］Wang W，J Liu，Q Wu. MiR-205 suppresses autophagy and enhances radiosensitivity of prostate cancer cells by targeting TP53INP1. Eur Rev Med Pharmacol Sci，2016，20（1）：92-100.

［365］Srivastava A，Goldberger H，Dimtchev A，et al. MicroRNA profiling in prostate cancer-the diagnostic potential of urinary miR-205 and miR-214. PLoS One，2013，8（10）：e76994.