参考文献

1.卫旭东，何健.端粒和端粒酶与肿瘤干细胞的研究现状.中华肿瘤防治杂志，2011，9：730-733.

2.DePamphilis ML.Replication origins in metazoan chromosomes：fact or fiction Bioessays，1999，21：5-9.

3.MOR IN GB.The human telomere terminal transferase enzyme is a ribonu-cleoprotein synthesizes TTAGGG repeats.Cell，1989，1：5192521.

4.卫旭东，周梁.实体瘤肿瘤干细胞的研究进展.中华肿瘤防治杂志，2007，14（15）：1184-1186.

5.Collins K.The biogenesis and regulation of telomerase holoenzymes.Nature reviews Mol Cell Biol，2006，7：484-494.

6.Morin GB.The human telomere terminal transferase enzyme is a ribonucleop rotein that synthesizes TTAGGG repeats.Cell，1989，59（3）：521-529.

7.GREIDER CW，BLACKBURN EH.Identification of a specific telomere terminal transferase activity in Tetrahymena exracts.Cell，1985（2）：405-413.

8.Karlseder J，Broccoli D，Dai Y，et al.TRF2 protects telomeres from end- to- end fusions.Cell，1998，92：401.

9.Baumann P，Podell P，Cech TR.Human Pot1（Protection of Telomeres）protein：Cytolocalization，gene structure，and alternative splicing.Mol Cell Biol，2002，20：8079.

10.Zhou Xiao Zhen，Lu Kun Ping.The Pin2 /TRF1- interacting protein PinX1 is a potent telomerase inhibitor.Cell，2001，107：347

11.杨平勋，黄君健.端粒及端粒酶的研究进展.生物技术通讯，2007，18（4）：667-669.

12.Bryan TM，Englezou A，Gupta J，et al.Telomere elongation in immortal human cells without detectable telomerase activity.E MB，1995，14：42- 40.

13.Blasco MA，Lee HW，Hande MP，et al.Telomere short ening and tumor format ion by mouse cells lacking telomerase RNA.Cell，1997，91：25-34.

14.Kim NW，Piat yszek MA，Prowse KR，et al.Specific association of human telomerase act ivity with immortal cells and cancer.Science，1994，266：2011-2015.

15.O’Sullivan JN，Bronner MP，Brentnall TA，et al.Chromosomal instability in ulcerative colitis is related to telomere shortening.Nat Genet，2002，32：280-284.

16.Plentz RR，Schlegelberger B，Flemming P，et al.Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma.Hepatology，2005，42（3）：522-526.

17.Harley CB，Futcher AB，Greider CW.Telomeres shorten during ageing of human fibroblasts.Nature，1990，345（6274）：458- 460.

18.DAdda DF，Reaper PM，Clay-Farrace L，et al.A DNA damage checkpoint response in telomere-initiated senescence.Nature，2003，426：194-198.

19.Rudolph KL，Millard M，Bosenberg MW，et al.Telomere dysfunction and evolution of intestinal carcinoma in mice and humans.Nat Genet，2001，28：155-159.

20.Artandi SE，Chang S，Lee SL，et al.Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.Nature，2000，406：641-645.

21.Plentz RR，Schlegelberger B，Flemming P，et al.Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma.Hepatology，2005，42（3）：522-526.

22.Djojosubroto MW，Choi YS，Lee HW，et al.Telomeres and telomerase in aging，regeneration and cancer.Mol Cells，2003，15：164-175.

23.Gonzalez-Suarez E，Samper E，Flores JM，et al.Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.Nat Genet，2000，26：114-117.

24.Artandi SE，Alson S，Tietze MK，et al.Constitutive telomerase expression promotes mammary carcinomas in aging mice.Proc Natl Acad Sci USA，2002，99：8191-8196.

25.Smith LL，Coller HA，Roberts JM.Telomerase modulatesexpression of growth-controlling genes and enhances cell proliferation.Nat Cell Biol，2003，5：474-479.

26.Bonnet D，Dick IE.Human acute myeloid leukemia is organized as a hierarchy that origination from a primitive hematopoietic cell.Nature Med，1997，3（7）：730-737.

27.Ohyashiki JH，Sashida G，Tauchi T，et al.Telomeres and telomerase in hematologic neoplasia.Oncogene，2002，21：680-687.

28.Brummendorf TH，Holyoake TL，Rufer N，et al.Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry.Blood，2000，95：1883-1890.

29.Mason PJ，Wilson DB，Bessler M.Dyskeratosis congenita - a disease of dysfunctional telomere maintenance.Curr Mol Med，2005，5：159-170.

30.Ohyashiki JH，Sashida G，Tauchi T，et al.Telomeres and telomerase in hematologic neoplasia.Oncogene，2002，21：680-687.

31.Zhenyu Ju，Karl Lenhard Rudolph.Telomeres and telomerase in cancer stem cells.European Journal of Cancer，2006，42：1197-1203.

32.Cagatay Gunes，K Lenhard Rudolph.The Role of Telomeres in Stem Cells and Cancer.Cell，2013，152（31）：390-393.

33.Alessandra Sacco，Foteini Mourkioti，Rose Tran，et al.Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice.Cell，2010，143（23）：1059-1071.

34.S Carla A Theimer，Juli Feigon.Structure and function of telomerase RNA.Current Opinion in Structural Biology，2006，16：307-318.

35.Paula Martínez，María A.BlascoTelomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.Nature Reviews，2011，11：161-175.

36.Sophie Georgin-Lavialle，Achille Aouba，Luc Mouthon，et al.The telomere/telomerase system in autoimmune and systemic immune-mediated diseases.Autoimmunity Reviews，2010，9：646-651.

37.M ARMANIOS，CW GREIDER.Telomerase and Cancer Stem Cells.Cold Spring Harb Symp Quant Biol，2005，70：205-208.

38.Helen B Fleisig，Judy MY Wong.Telomerase as a clinical target：Current strategies and potential applications.Experimental Gerontology，2007，42：102-112.

39.Ignacio Flores，Roberta Benetti，Maria A Blasco.Telomerase regulation and stem cell behaviour.Current Opinion in Cell Biology，2006，18：254-260.